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Hypoxia upregulateing ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

2023-10-09

Abstract excerpt

<title>Abstract</title> <p>Background Pancreatic neuroendocrine neoplasms(pNENs) are a relatively rare disease.Hypoxia and lipid metabolism-related gene acetyl-CoA synthetase 2(ACSS2) is involved in tumor progression,but its role in pNENs is not revealed.This study showed that hypoxia can upregulate ACSS2,which plays an important role in the occurrence and development of pNENs through lipid metabolism reprogramm...

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Literature Corpus work
2c422451-45a9-5fa7-9b59-0d1665cc20f2
DOI
10.21203/rs.3.rs-3398110/v1
Open publication

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Hypoxia upregulateing ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasmsDOI 10.21203/rs.3.rs-3398110/v1
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