ANGPTL4 Negatively Regulate the Progression of Osteosarcoma by Remodeling Branched-Chain Amino Acid Metabolism

Abstract excerpt

<h4>Background: </h4> Angiopoietin-like-4 (ANGPTL4), a secreted glycoprotein that is mainly recognized as a regulator in lipid metabolism, now, is implied in the regulation of the growth and metastasis of various carcinomas. However, less is known about its functions in the progression of sarcomas, let alone osteosarcoma (OS), which is the most common malignant diagnosed in musculoskeletal system. <h4>Methods: </h...

Topics

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• Annexin A2
• Apoptosis
• Bone Neoplasms
• Cancer-related molecular mechanisms research
• Glycolysis
• Osteosarcoma
• Proto-Oncogene Proteins c-akt
• S100 Proteins

Identifiers and source

Literature Corpus work

fa104eab-0ae9-5572-b657-b3698307ca3f

DOI

10.21203/rs.3.rs-1209880/v1