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Article

Brain-derived neurotrophic factor and obesity in the WAGR syndrome.

The New England journal of medicine - 28 Aug 2008

Han Joan C, Liu Qing-Rong, Jones MaryPat, Levinn Rebecca L, Menzie Carolyn M, Jefferson-George Kyra S, Adler-Wailes Diane C, Sanford Ethan L, Lacbawan Felicitas L, Uhl George R, Rennert Owen M, Yanovski Jack A

Abstract excerpt

BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been found to be important in energy homeostasis in animal models, but little is known about its role in energy balance in humans. Heterozygous, variably sized, contiguous gene deletions causing haploinsufficiency of the WT1 and PAX6 genes on chromosome 11p13, approximately 4 Mb centromeric to BDNF (11p14.1), result in the Wilms' tumor, aniridia,...

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Identifiers

PMID: 18753648
DOI: 10.1056/NEJMoa0801119
PMCID: PMC2553704

Genes

BDNF
PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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