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Article

Relevance of the COPI complex for Alzheimer’s disease progression in vivo

25 Apr 2016

Abstract excerpt

Cellular trafficking and recycling machineries belonging to late secretory compartments have been associated with increased Alzheimer's disease (AD) risk. We have shown that coat protein complex I (COPI)-dependent trafficking, an early step in Golgi-to-endoplasmic reticulum retrograde transport, affects amyloid precursor protein subcellular localization, cell-surface expression, as well as its metabolism. We...

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PMID: 27114526
DOI: 10.1073/pnas.1604176113

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Related research

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Research trail→

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Relevance of the COPI complex for Alzheimer’s disease progression in vivoPMID 27114526Read ↗

Mutations in the COPI coatomer subunit α-COP induce release of Aβ-42 and amyloid precursor protein intracellular domain and increase tau oligomerization and release.Semantic proximity Read ↗

Assembly, organization, and function of the COPII coatSemantic proximity Read ↗

The COPI coatomer regulates several steps of HDL metabolismSemantic proximity Read ↗

The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretionSemantic proximity Read ↗

Cex1 is a component of the COPI intracellular trafficking machinery.Semantic proximity Read ↗

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.Semantic proximity Read ↗

Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic.Semantic proximity Read ↗

Sequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum to Golgi transport.Semantic proximity Read ↗

Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoinﬂammatory syndrome.Semantic proximity Read ↗

Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking PathwaySemantic proximity Read ↗

Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly.Semantic proximity Read ↗

Traffic COPs of the Early Secretory PathwaySemantic proximity Read ↗

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