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Article

Comparison of statistical tests for association between rare variants and binary traits.

PloS one - 1 Jan 2012

Bacanu Silviu-Alin, Nelson Matthew R, Whittaker John C

Abstract excerpt

Genome-wide association studies have found thousands of common genetic variants associated with a wide variety of diseases and other complex traits. However, a large portion of the predicted genetic contribution to many traits remains unknown. One plausible explanation is that some of the missing variation is due to the effects of rare variants. Nonetheless, the statistical analysis of rare variants is...

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PMID: 22912707
DOI: 10.1371/journal.pone.0042530
PMCID: PMC3415421

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