Article

Angiopoietin like protein 3 regulates low-density lipoprotein transport through aortic endothelial cells via endothelial lipase

2025-10-01

Abstract excerpt

Angiopoietin-like protein 3 (ANGPTL3) inhibits endothelial lipase (EL, encoded by LIPG) and lipoprotein lipase (LPL) and has emerged as a promising target for lipid-lowering therapies. While ANGPTL3 inhibition lowers circulating triglycerides and low-density lipoprotein cholesterol (LDL-C), its impact on atherosclerotic cardiovascular disease (ASCVD) remains uncertain. This study investigates the roles of ANGPTL3...

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Literature Corpus work: 2bc4fc1f-16c9-5935-a566-6fa14d734929
DOI: 10.1101/2025.09.30.679508

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