Article

Endothelial lipase facilitates low-density lipoprotein (LDL) uptake in LDL receptor deficiency by a heparan sulfate proteoglycan-dependent mechanism

2025-03-10

Abstract excerpt

<h4>ABSTRACT</h4> Current lipid-lowering drugs are relatively ineffective in reducing low-density lipoprotein (LDL) cholesterol in patients with Familial Hypercholesterolemia (FH) due to a dysfunctional LDL receptor (LDLR). However, LDL cholesterol reductions have been achieved in FH patients using angiopoietin-like 3 (ANGPTL3) inhibitors, which act through an uncharacterized, LDLR-independent pathway that requir...

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Literature Corpus work: 5625e6ef-f7f0-58ee-810e-2e552d001b03
DOI: 10.1101/2025.03.02.640965

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