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Article

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

1 Apr 2017

Abstract excerpt

BACKGROUND: Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether ANGPTL3 deficiency reduces risk of coronary artery disease (CAD) is unknown. OBJECTIVES: The study goal was to leverage 3 distinct lines of evidence-a family that included individuals with...

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Identifiers

PMID: 28385496
DOI: 10.1016/j.jacc.2017.02.030

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