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Article

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST.

Science advances - 24 Jan 2025

Kraus Felix, He Yuchen, Swarup Sharan, Overmyer Katherine A, Jiang Yizhi, Brenner Johann, Capitanio Cristina, Bieber Anna, Jen Annie, Nightingale Nicole M, Anderson Benton J, Lee Chan, Paulo Joao A, Smith Ian R, Plitzko Jürgen M, Gygi Steven P, Schulman Brenda A, Wilfling Florian, Coon Joshua J, Harper J Wade

Abstract excerpt

Lysosomal storage diseases (LSDs) comprise ~50 monogenic disorders marked by the buildup of cellular material in lysosomes, yet systematic global molecular phenotyping of proteins and lipids is lacking. We present a nanoflow-based multiomic single-shot technology (nMOST) workflow that quantifies HeLa cell proteomes and lipidomes from over two dozen LSD mutants. Global cross-correlation analysis between lipids and...

Read the complete abstract on PubMed

Topics

Humans
Lysosomal Storage Diseases
HeLa Cells
Mutation
Lysosomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Lipidomics

Proteomics

Mitochondria

Proteome

Autophagy

Source

Open in PubMed Open full text

Identifiers

PMID: 39841834
DOI: 10.1126/sciadv.adu5787
PMCID: PMC11753374

Genes

NPC2
NPC1

Provenance

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