Article

Conservation of specificity in two low-specificity protein

2017-10-25

Abstract excerpt

S100 proteins bind linear peptide regions of target proteins and modulate their activity. The peptide binding interface, however, has remarkably low specificity and can interact with many target peptides. It is not clear if the interface discriminates targets in a biological context, or whether biological specificity is achieved exclusively through external factors such as subcellular localization. To discriminate...

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Literature Corpus work: 2ba8df84-9dc4-5f82-b04a-548e2a884df1
DOI: 10.1101/207324

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