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Article

Testing whether metazoan tyrosine loss was driven by selection against promiscuous phosphorylation.

Molecular biology and evolution - 1 Jan 2015

Pandya Siddharth, Struck Travis J, Mannakee Brian K, Paniscus Mary, Gutenkunst Ryan N

Abstract excerpt

Protein tyrosine phosphorylation is a key regulatory modification in metazoans, and the corresponding kinase enzymes have diversified dramatically. This diversification is correlated with a genome-wide reduction in protein tyrosine content, and it was recently suggested that this reduction was dr...

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Identifiers

PMID: 25312910
DOI: 10.1093/molbev/msu284
PMCID: PMC4271526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25312910-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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