Article
Testing whether metazoan tyrosine loss was driven by selection against promiscuous phosphorylation.
Molecular biology and evolution - 1 Jan 2015
Pandya Siddharth, Struck Travis J, Mannakee Brian K, Paniscus Mary, Gutenkunst Ryan N
Abstract excerpt
Protein tyrosine phosphorylation is a key regulatory modification in metazoans, and the corresponding kinase enzymes have diversified dramatically. This diversification is correlated with a genome-wide reduction in protein tyrosine content, and it was recently suggested that this reduction was driven by selection to avoid promiscuous phosphorylation that might be deleterious. We tested three predictions of this...
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