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A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection

20 May 2024

Abstract excerpt

Viral disruption of innate immune signaling is a critical determinant of productive infection. The Human Cytomegalovirus (HCMV) UL26 protein prevents anti-viral gene expression during infection, yet the mechanisms involved are unclear. We used TurboID-driven proximity proteomics to identify putative UL26 interacting proteins during infection to address this issue. We find that UL26 forms a complex with several...

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Cytomegalovirus and herpesvirus research
interferon and immune responses
Toxoplasma gondii Research Studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38768227
DOI: 10.1371/journal.ppat.1012058

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