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Article

FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin.

The Journal of clinical investigation - 1 Oct 2012

Kode Aruna, Mosialou Ioanna, Silva Barbara C, Rached Marie-Therese, Zhou Bin, Wang Ji, Townes Tim M, Hen Rene, DePinho Ronald A, Guo X Edward, Kousteni Stavroula

Abstract excerpt

Serotonin is a critical regulator of bone mass, fulfilling different functions depending on its site of synthesis. Brain-derived serotonin promotes osteoblast proliferation, whereas duodenal-derived serotonin suppresses it. To understand the molecular mechanisms of duodenal-derived serotonin action on osteoblasts, we explored its transcriptional mediation in mice. We found that the transcription factor FOXO1 is a...

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Share to Activating Transcription Factor 4
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclic AMP Response Element-Binding Protein

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Share to Forkhead Box Protein O1

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Receptor, Serotonin, 5-HT1B

Source

Open in PubMed Open full text

Identifiers

PMID: 22945629
DOI: 10.1172/JCI64906
PMCID: PMC3461930

Genes

FOXO1
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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