Targeted next-generation sequencing of matched localized and metastatic primary high-risk SCCs identifies driver and co-occurring mutations and novel therapeutic targets.

Abstract excerpt

BACKGROUND: Cutaneous squamous cell carcinoma (SCC) is the second most common type of skin cancer and is responsible for over one million cases annually. While only 3-5 % of SCCs metastasize, those that do are associated with significant morbidity and mortality. Using gene mutations to help predict metastasis and select therapeutics is still being explored. OBJECTIVE: To present novel data from targeted...

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• AMP-Activated Protein Kinase Kinases
• Antineoplastic Agents, Alkylating
• Cadherins
• Carcinogenesis
• Molecular Targeted Therapy