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mTORC1 syndrome (TorS): unified paradigm for diabetes/metabolic syndrome

28 Jan 2023

Abstract excerpt

'Glucolipotoxicity' and 'insulin resistance' are claimed to drive type 2 diabetes (T2D) and the non-glycemic diseases of the metabolic syndrome (MetS) (obesity, dyslipidemia, hypertension). In line with that, glycemic and/or insulin control are considered to be primary goal in treating T2D/MetS. However, recent standard-of-care (SOC) treatments of T2D, initially designed to control T2D hyperglycemia, appear now...

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PMID: 36717300
DOI: 10.1016/j.tem.2023.01.001

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