Article

Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2

2020-05-12

Abstract excerpt

<h4>A bstract </h4> Polymorphisms in MHC-I protein sequences across human populations significantly impacts viral peptide binding capacity and thus alters T cell immunity to infection. Consequently, allelic variants of the MHC-I protein have been found to be associated with patient outcome to various viral infections, including SARS-CoV. In the present study, we assess the relationship between observed SARS-CoV-2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b235437-13d1-5197-ac61-fdb4c79ca477
DOI: 10.1101/2020.05.08.20095430

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2DOI 10.1101/2020.05.08.20095430Read

Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2.Semantic proximity Read

Population-Predicted MHC Class II Epitope Presentation of SARS-CoV-2 Structural Proteins Correlates to the Case Fatality Rates of COVID-19 in Different Countries.Semantic proximity Read

Antigen coverage presented by MHC class I has a negative correlation with SARS-CoV-2-induced mortalitySemantic proximity Read

HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 diseaseSemantic proximity Read

The T cell epitope landscape of SARS-CoV-2 variants of concernSemantic proximity Read

Class I HLA allele predicted antigenic coverages for Spike and Nucleocapsid proteins are associated with deaths related to COVID-19Semantic proximity Read

Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants.Semantic proximity Read

A bioinformatic analysis of T-cell epitope diversity in SARS-CoV-2 variants: association with COVID-19 clinical severity in the United States population.Semantic proximity Read

Class I HLA Allele Predicted Restricted Antigenic Coverages for Spike and Nucleocapsid Proteins Are Associated With Deaths Related to COVID-19Semantic proximity Read

A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4 <sup>+</sup> T cellsSemantic proximity Read

Influence of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Population and Individual Level.Semantic proximity Read

High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escapeSemantic proximity Read