Article
Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Sept 2020
de Sousa Eric, Ligeiro Dário, Lérias Joana R, Zhang Chao, Agrati Chiara, Osman Mohamed, El-Kafrawy Sherif A, Azhar Esam I, Ippolito Giuseppe, Wang Fu-Sheng, Zumla Alimuddin, Maeurer Markus
Abstract excerpt
Genetic factors such as the HLA type of patients may play a role in regard to disease severity and clinical outcome of patients with COVID-19. Taking the data deposited in the GISAID database, we made predictions using the IEDB analysis resource (TepiTool) to gauge how variants in the SARS-CoV-2 genome may change peptide binding to the most frequent MHC-class I and -II alleles in Africa, Asia and Europe. We...
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