Article
A bioinformatic analysis of T-cell epitope diversity in SARS-CoV-2 variants: association with COVID-19 clinical severity in the United States population.
Frontiers in immunology - 1 Jan 2024
Kim Grace J, Elnaggar Jacob H, Varnado Mallory, Feehan Amy K, Tauzier Darlene, Rose Rebecca, Lamers Susanna L, Sevalia Maya, Nicholas Najah, Gravois Elizabeth, Fort Daniel, Crabtree Judy S, Miele Lucio
Abstract excerpt
Long-term immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the identification of T-cell epitopes affecting host immunogenicity. In this computational study, we explored the CD8+ epitope diversity estimated in 27 of the most common HLA-A and HLA-B alleles, representing most of the United States population. Analysis of 16 SARS-CoV-2 variants [B.1, Alpha (B.1.1.7), five Delta...
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