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Article

Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2.

Cell reports. Medicine - 16 Mar 2021

Wilson Eric A, Hirneise Gabrielle, Singharoy Abhishek, Anderson Karen S

Abstract excerpt

Polymorphisms in MHC-I protein sequences across human populations significantly affect viral peptide binding capacity, and thus alter T cell immunity to infection. In the present study, we assess the relationship between observed SARS-CoV-2 population mortality and the predicted viral binding capacities of 52 common MHC-I alleles. Potential SARS-CoV-2 MHC-I peptides are identified using a consensus MHC-I binding...

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Identifiers

PMID: 33649748
DOI: 10.1016/j.xcrm.2021.100221
PMCID: PMC7904449

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