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Article

HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease

5 Jul 2021

Abstract excerpt

BACKGROUND: The worldwide pandemic caused by the SARS-CoV-2 virus is characterized by significant and unpredictable heterogeneity in symptoms that remains poorly understood. METHODS: Transcriptome and single cell transcriptome of COVID19 lung were integrated with deeplearning analysis of MHC class I immunopeptidome against SARS-COV2 proteome. RESULTS: An analysis of the transcriptomes of lung samples from...

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PMID: 34225749
DOI: 10.1186/s12967-021-02965-5

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