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IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity against neuroblastoma

2025-04-24

Abstract excerpt

Invariant natural killer T cells (NKTs) have intrinsic anti-tumor properties that make them promising candidates for chimeric antigen receptor (CAR)-based immunotherapies. Transgenic cytokine expression has been shown to enhance the potency of cellular immunotherapies, and we hypothesized that co-expressing IL-18 alone or with IL-15 would boost CAR-NKT therapeutic potential. To test this hypothesis, we generated r...

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Identifiers and source

Literature Corpus work
2b1be90f-2121-52fa-9a57-2080873297e5
DOI
10.1101/2025.04.18.649551
Open publication

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IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity against neuroblastomaDOI 10.1101/2025.04.18.649551
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