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Article

Interleukin-15-armored GPC3-CAR T cells for patients with solid cancers

2024-04-03

Abstract excerpt

<title>Abstract</title> <p>Interleukin-15 (IL15) promotes the survival of T lymphocytes and enhances the antitumor properties of CAR T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1-4. Glypican-3 (GPC3) is expressed in a group of solid cancers5-10, and here we report the first evaluation in humans of the effects of IL15 co-expression on GPC3-CAR T cells. Cohort 1 patien...

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Identifiers and source

Literature Corpus work
145a06d5-49c6-5ce4-bf32-14c755a20344
DOI
10.21203/rs.3.rs-4103623/v1
Open publication

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Interleukin-15-armored GPC3-CAR T cells for patients with solid cancersDOI 10.21203/rs.3.rs-4103623/v1
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