Article

Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies

2026-08-18

Abstract excerpt

SARS-CoV-2 evolution has reduced the efficacy of clinical monoclonal antibodies, underscoring the need for therapeutics targeting conserved viral regions. The Spike (S) heptad repeat 2 (HR2) stem helix is highly conserved across SARS-CoV-2 variants and related betacoronaviruses. Although antibodies to this region can neutralize infection, their natural occurrence and evolution remain poorly understood. We previous...

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Literature Corpus work: 2af908bc-848a-5bb4-934d-902a9607a275
DOI: 10.64898/2026.08.17.745160

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