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Comparison of Pooled and Bayesian population PK approaches in pediatric PK analysis leveraging prior adult knowledge: A case study exploring considerations for mAbs

2026-05-12

Abstract excerpt

<b>Aim</b> Population pharmacokinetic (popPK) modeling is widely used to support pediatric dosing within pediatric extrapolation frameworks, yet consensus on appropriate modeling approaches remains limited. This study aimed to compare Pooled and Bayesian popPK approaches for pediatric PK analysis using a monoclonal antibody (mAb) example, focusing on bias and precision of parameter estimates. <b>Methods</b> Pediat...

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Literature Corpus work
2af19060-8dba-5ba5-9f72-4c2b79424475
DOI
10.22541/authorea.15003122/v1
Open publication

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Comparison of Pooled and Bayesian population PK approaches in pediatric PK analysis leveraging prior adult knowledge: A case study exploring considerations for mAbsDOI 10.22541/authorea.15003122/v1
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