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Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Mar 2022

Zhan Min, Sun Yiqi, Zhou Fang, Wang Honghong, Chen Zebin, Yan Lianzhen, Li Xingang

Abstract excerpt

This study aimed to identify physiological and pharmacogenomic covariates and develop a population pharmacokinetic model of high-dose methotrexate (HD-MTX) in Chinese paediatric patients with acute lymphoblastic leukaemia (ALL) and malignant lymphoma.A total of 731 MTX courses and 1658 MTX plasm concentrations from 205 paediatric patients with ALL and malignant lymphoma were analysing using a non-linear...

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Identifiers

PMID: 35446233
DOI: 10.1080/00498254.2022.2069060

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