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Physiologically-based pharmacokinetic models versus allometric scaling for prediction of tyrosine-kinase inhibitor exposure from adults to children

2023-12-08

Abstract excerpt

<h4>Purpose: </h4> Model-based methods can predict pediatric exposure and support initial dose selection. The aim of this study was to evaluate the performance of allometric scaling of population pharmacokinetic (popPK) versus physiologically based pharmacokinetic (PBPK) models in predicting the exposure of tyrosine kinase inhibitors (TKIs) for pediatric patients (≥ 2 years), based on adult data. The drugs imatini...

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Literature Corpus work
1ca06750-ab3b-57f7-a489-88b93b460491
DOI
10.21203/rs.3.rs-3709185/v1
Open publication

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