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Protocol for Bayesian combined multi-genotype and concentration informed tacrolimus dosing in paediatric solid organ transplantation (BRUNO-PIC)

2025-05-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Tacrolimus is an immunosuppressant used extensively in solid organ transplantation. Whilst highly effective in preventing organ rejection, it has a narrow range of safe and effective concentrations and wide pharmacokinetic variability, which can lead to and suboptimal outcomes or unacceptable toxicities. Importantly, much is known about the sources of pharmacokinetic varia...

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Literature Corpus work
b64937ed-f0eb-5fdf-8f46-3ef0a35cd1cf
DOI
10.1101/2025.05.06.25327120
Open publication

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