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Article

A spatially resolved timeline of the human maternal–fetal interface

19 Jul 2023

Abstract excerpt

Abstract Beginning in the first trimester, fetally derived extravillous trophoblasts (EVTs) invade the uterus and remodel its spiral arteries, transforming them into large, dilated blood vessels. Several mechanisms have been proposed to explain how EVTs coordinate with the maternal decidua to promote a tissue microenvironment conducive to spiral artery remodelling (SAR) 1–3 . However, it remains a matter of...

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PMID: 37468587
DOI: 10.1038/s41586-023-06298-9

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