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Article

Application of a JEG-3 organoid model to study HLA-G function in the trophoblast

15 Mar 2023

Abstract excerpt

The human placenta is a unique temporary organ with a mysterious immune tolerance. The formation of trophoblast organoids has advanced the study of placental development. HLA-G is uniquely expressed in the extravillous trophoblast (EVT) and has been linked to placental disorders. With older experimental methodologies, the role of HLA-G in trophoblast function beyond immunomodulation is still contested, as is its...

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PMID: 37006248
DOI: 10.3389/fimmu.2023.1130308

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