Early EGFR Inhibition Triggers Actionable Tumor and Microenvironmental Remodeling in Lung Cancer.

doi:10.1158/2767-9764.CRC-26-0073

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Early EGFR Inhibition Triggers Actionable Tumor and Microenvironmental Remodeling in Lung Cancer.

Cancer research communications - 1 Aug 2026

Tan Aaron C, Yeo Jia Chi, Alvarez Jacob J S, Pang Mengyuan, Guo Yu Amanda, Hoo Regina, Takano Angela M, Ong Boon-Hean, Goh Denise, Yeong Joe, Wu Zhengwei, Yuan Ju, Shathishwaran S, Sim Ngak Leng, Chua Khi Pin, Tam Wai Leong, Wang Lan Ying, Lau Dawn P X, Saw Stephanie P, Jain Amit, Lai Gillianne G, Tan Wan Ling, Ang Mei Kim, Ng Quan Sing, Kanesvaran Ravindran, Lim Darren W, Skanderup Anders J, Tan Daniel S

Abstract excerpt

PURPOSE: Despite widespread use of targeted therapies, little is known about how tumors and their microenvironment respond in the earliest phases of treatment and whether these early changes reveal new therapeutic opportunities. In this study, we investigated how short-term epidermal growth factor receptor (EGFR) inhibition reshapes tumor biology and the tumor microenvironment using comprehensive multiregion and...

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Aged
Carcinoma, Non-Small-Cell Lung
ErbB Receptors
Gefitinib

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung Neoplasms

Neoadjuvant Therapy

Protein Kinase Inhibitors

Tumor Microenvironment

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Identifiers

PMID: 42579877
DOI: 10.1158/2767-9764.CRC-26-0073
PMCID: PMC13510642

Genes

EGFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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