Article
CancerTracer: a curated database for intrapatient tumor heterogeneity.
Nucleic acids research - 8 Jan 2020
Wang Chen, Yang Jian, Luo Hong, Wang Kun, Wang Yu, Xiao Zhi-Xiong, Tao Xiang, Jiang Hao, Cai Haoyang
Abstract excerpt
Comprehensive genomic analyses of cancers have revealed substantial intrapatient molecular heterogeneities that may explain some instances of drug resistance and treatment failures. Examination of the clonal composition of an individual tumor and its evolution through disease progression and treatment may enable identification of precise therapeutic targets for drug design. Multi-region and single-cell sequencing...
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