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Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs

14 Oct 2021

Abstract excerpt

Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes. It is characterized by the pathogenic triad: microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms modulate gene expression without interfering with the DNA sequence. Epigenetic marks may be reversible and their differential response to external stimuli could explain the protean clinical...

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PMID: 34680587
DOI: 10.3390/biomedicines9101471

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