Article

Active synthesis of type I collagen homotrimer in Dupuytren’s fibrosis is unaffected by anti-TNF-α treatment

2020-07-14

Abstract excerpt

Dupuytren’s disease is a common fibroproliferative disease of the palmar fascia of the hand with advanced cases treated surgically. Anti-tumour necrosis factor (TNF) injection has undergone phase 2 trials and may be effective in slowing early-stage disease progression. Here we sought to determine how new synthesis of type I collagen in Dupuytren’s differs from normal palmar fascia samples and to analyse the role o...

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Literature Corpus work: 2aa302af-8f25-58cf-8bd0-ed8da1515f23
DOI: 10.1101/2020.07.13.195107

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