Article
Dupuytren disease: an evolving understanding of an age-old disease.
The Journal of the American Academy of Orthopaedic Surgeons - 1 Dec 2011
Black Eric M, Blazar Philip E
Abstract excerpt
Dupuytren disease, a clinical entity originally described more than 400 years ago, is a progressive disease of genetic origin. Excessive myofibroblast proliferation and altered collagen matrix composition lead to thickened and contracted palmar fascia; the resultant digital flexion contractures may severely limit function. The pathophysiology is multifactorial and remains a topic of research and debate. Genetic...
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