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Article

Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2013

Verjee Liaquat S, Verhoekx Jennifer S N, Chan James K K, Krausgruber Thomas, Nicolaidou Vicky, Izadi David, Davidson Dominique, Feldmann Marc, Midwood Kim S, Nanchahal Jagdeep

Abstract excerpt

Dupuytren's disease is a very common progressive fibrosis of the palm leading to flexion deformities of the digits that impair hand function. The cell responsible for development of the disease is the myofibroblast. There is currently no treatment for early disease or for preventing recurrence following surgical excision of affected tissue in advanced disease. Therefore, we sought to unravel the signaling...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23431165
DOI: 10.1073/pnas.1301100110
PMCID: PMC3593900

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.PMID 23431165Read ↗

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