Article

Semaphorin 3F Induces Colorectal Cancer Cell Chemosensitivity by Promoting P27 Nuclear Export

2022-01-25

Abstract excerpt

<h4>Background: </h4> Colorectal adenocarcinoma (CRC) is the third most common malignancy worldwide. Metastatic CRC (mCRC) has a poor prognosis and high mortality rate because of chemotherapy resistance, and the overall 5-year survival rate of mCRC is only 14%. Our previous study demonstrated that semaphorin 3F (SEMA3F) signaling may contribute to reversing chemotherapy resistance in CRC cells by reducing E-cadher...

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Literature Corpus work: 2a7108b5-422e-501d-a973-5a4e42f0e71f
DOI: 10.21203/rs.3.rs-1285541/v1

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