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Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer

20 Mar 2017

Abstract excerpt

) in 3D and xenografts. Analysis of a CRC tissue microarray showed that epithelial, but not stromal, VCAN staining strongly correlated with reduced survival, and combined epithelial VCAN and absent HPGD staining portended a poorer prognosis. Thus, with this 3D system, we have identified a mode of cetuximab resistance and a potential prognostic marker in CRC. As such, this represents a potentially powerful system...

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PMID: 28320945
DOI: 10.1073/pnas.1618297114

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