Back to search

Article

Short-term heritable variation overwhelms two hundred generations of mutational variance for metabolic traits in <i>Caenorhabditis elegans</i>

2020-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic disorders have a large heritable component, and have increased over the past few generations. Genome-wide association studies of metabolic traits typically find a substantial unexplained fraction of total heritability, suggesting an important role of spontaneous mutation. An alternative explanation is that epigenetic effects contribute significantly to the heritable variation. Here we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2a62302e-4993-5309-abdf-852a15bd9092
DOI
10.1101/2020.02.05.935197
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Short-term heritable variation overwhelms two hundred generations of mutational variance for metabolic traits in <i>Caenorhabditis elegans</i>DOI 10.1101/2020.02.05.935197
Short-term heritable variation overwhelms 200 generations of mutational variance for metabolic traits in Caenorhabditis elegans.Semantic proximity
The mutational structure of metabolism in Caenorhabditis elegans.Semantic proximity
Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans.Semantic proximity
Systems genetics of the Drosophila metabolome.Semantic proximity
Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a <i>C. elegans</i> propionic acidemia modelSemantic proximity
Prediction of complex phenotypes using the <i>Drosophila</i> metabolomeSemantic proximity
The Establishment of Transgenerational Epigenetic Inheritance in the <i>C. elegans</i> Germline is Mediated by Lipid MetabolismSemantic proximity
Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster.Semantic proximity
Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved Drosophila melanogaster Populations.Semantic proximity
Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA.Semantic proximity
Escherichia coli Metabolite Profiling Leads to the Development of an RNA Interference Strain for Caenorhabditis elegans.Semantic proximity
Caenorhabditis Elegans as a Model for Environmental EpigeneticsSemantic proximity
Select a neighboring publication to make it the new centre.