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Article

The mutational structure of metabolism in Caenorhabditis elegans.

Evolution; international journal of organic evolution - 1 Oct 2016

Davies Sarah K, Leroi Armand, Burt Austin, Bundy Jacob G, Baer Charles F

Abstract excerpt

A properly functioning organism must maintain metabolic homeostasis. Deleterious mutations degrade organismal function, presumably at least in part via effects on metabolic function. Here we present an initial investigation into the mutational structure of the Caenorhabditis elegans metabolome by means of a mutation accumulation experiment. We find that pool sizes of 29 metabolites vary greatly in their...

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Identifiers

PMID: 27465022
DOI: 10.1111/evo.13020
PMCID: PMC5050113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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