Article
Nutrient regulation of the islet epigenome controls adaptive insulin secretion
2019-08-21
Abstract excerpt
Adaptation of the islet β-cell insulin secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we show that nutrient-stimulated histone acetylation plays a key role in adapting insulin secretion through regulation of genes involved in β-cell nutrient sensing and metabolism. Nutrient regulation of the epigenome occurs...
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Identifiers and source
- Literature Corpus work
- 29c814c1-4412-5be6-9d37-d1bdc7c8f6ee
- DOI
- 10.1101/742403