Article

TM6SF2/PNPLA3/MBOAT7 loss-of-function genetic variants impact on NAFLD development and progression both in patients and in <i>in vitro</i> models

2020-12-13

Abstract excerpt

<h4>Background and aims</h4> The I148M PNPLA3, the rs641738 in MBOAT7/TMC4 locus and the E167K TM6SF2 polymorphisms represent the main predisposing factors to non-alcoholic fatty liver disease (NAFLD) development and progression. We previously generated a full knockout of MBOAT7 in HepG2 cells (MBOAT7 -/- ), homozygous for the I148M PNPLA3. Therefore, we aimed to:1) investigate the synergic impact of the 3 at-...

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Literature Corpus work: 29c5d49c-46ba-51d6-91b2-46fc2da3ce62
DOI: 10.1101/2020.12.13.422549

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