HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes

Abstract excerpt

Abstract Human immunodeficiency virus 1 (HIV-1) infection is initiated by binding of the viral envelope glycoprotein (Env) to the cell-surface receptor CD4 1–4 . Although high-resolution structures of Env in a complex with the soluble domains of CD4 have been determined, the binding process is less understood in native membranes 5–13 . Here we used cryo-electron tomography to monitor Env–CD4 interactions at the...

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