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Epithelial tumor cells utilize mast cell-derived histamine to regulate perineural invasion

2025-06-27

Abstract excerpt

Cancer dissemination by perineural invasion (PNI) is associated with poor outcomes in epithelial malignancies, yet the cellular interactions critical to this process are not fully defined. Single-cell transcriptomic analysis of cutaneous squamous cell carcinoma (cSCC) with PNI highlighted KITLG - KIT signaling activation between keratinocytes and mast cells. Additionally, we observed increased expression of HRH...

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Identifiers and source

Literature Corpus work
29b30632-36f2-51ea-9bda-fbd690c900b0
DOI
10.1101/2025.06.23.661147
Open publication

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Epithelial tumor cells utilize mast cell-derived histamine to regulate perineural invasionDOI 10.1101/2025.06.23.661147
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