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Article

Neoadjuvant chemotherapy modulates mast cell phenotypes and immune infiltration in high-grade serous carcinoma.

Gynecologic oncology - 1 Dec 2025

Fan Yuanchun, Wang Qiuman, Deng Huiyan, Liu Yueping, Zhang Hui

Abstract excerpt

OBJECTIVE: The influence of neoadjuvant chemotherapy (NACT) on the immune landscape of high-grade serous carcinoma (HGSC) remains inadequately understood. This study aims to investigate the differential patterns of immune infiltration in HGSC tissues before and after NACT, as well as their clinical significance. METHODS: Immune infiltration patterns in HGSC tissues pre- and post-NACT were analyzed using our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41176887
DOI: 10.1016/j.ygyno.2025.10.014

Genes

KIT
CD52
JUN
TNFRSF12A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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