Article

Sex and genotype influence the disruption of circulating NMDAR-related amino acids in patients with Parkinson’s disease

2025-08-12

Abstract excerpt

Sex and genetic factors influence the epidemiology and clinical features of Parkinson’s disease (PD), but their impact on N-methyl-D-aspartate receptor (NMDAR)-related amino acids remains unclear. We measured serum levels of these molecules by high-performance liquid chromatography (HPLC) in a well-characterized cohort of PD patients (n = 245) and healthy controls (HCs, n = 203), stratified by sex and disease subt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2975f810-e4a2-50c0-a006-c1c435cdc3c4
DOI: 10.1101/2025.08.08.25333287

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex and genotype influence the disruption of circulating NMDAR-related amino acids in patients with Parkinson’s diseaseDOI 10.1101/2025.08.08.25333287Read

Discovery of Sexual Dimorphism in the Serum Metabolome of Parkinson’s Disease Patients Harboring Rare Genetic Variants with Uncertain PathogenicitySemantic proximity Read

Untargeted 1 H NMR-based metabolomics reveal sex-based differences in blood metabolome profiles among patients with Parkinson’s disease, regardless of their idiopathic or genetic subtypeSemantic proximity Read

Sex differences impact serum metabolome profiles in patients with familial Parkinson’s diseaseSemantic proximity Read

Unveiling Sex-based Differences in Parkinson's Disease: A Comprehensive Meta-analysis of Transcriptomic StudiesSemantic proximity Read

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s diseaseSemantic proximity Read

Mutations in the GBA1 , LRRK2 , TMEM175 , PARK2 , PINK1 , and PARK7 genes lead to sex-specific serum metabolic changes in patients with Parkinson’s diseaseSemantic proximity Read

Unveiling Sex-based Differences in Parkinson’s Disease: A Comprehensive Meta-analysis of Transcriptomic StudiesSemantic proximity Read

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's diseaseSemantic proximity Read

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease.Semantic proximity Read

Metabolomic Changes in Idiopathic and GBA1 Parkinson’s DiseaseSemantic proximity Read

The role of dopaminergic medication, lipid, and endocannabinoid pathway alterations in idiopathic andPRKN/PINK1-mediated Parkinson’s disease – a large-scale targeted metabolomics studySemantic proximity Read

Cerebrospinal fluid and plasma metabolites in Parkinson's disease: a Mendelian randomization study.Semantic proximity Read