Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection

6 Nov 2008

Abstract excerpt

Plasmodium sporozoites, the causative agent of malaria, are injected into their vertebrate host through the bite of an infected Anopheles mosquito, homing to the liver where they invade hepatocytes to proliferate and develop into merozoites that, upon reaching the bloodstream, give rise to the clinical phase of infection. To investigate how host cell signal transduction pathways affect hepatocyte infection, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to HIV Research and Treatment
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18989463
DOI: 10.1371/journal.ppat.1000201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite InfectionPMID 18989463Read ↗

Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profilesSemantic proximity Read ↗

The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission.Semantic proximity Read ↗

Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infectionSemantic proximity Read ↗

Inhibition of <i>Pf</i> CLK3 a master regulator of malaria parasite RNA-splicing provides the basis for a radical cure for malariaSemantic proximity Read ↗

Antimalarial drug discovery: targeting protein kinasesSemantic proximity Read ↗

Temperature Shift and Host Cell Contact Up-Regulate Sporozoite Expression of Plasmodium falciparum Genes Involved in Hepatocyte InfectionSemantic proximity Read ↗

Cas9-expressing HC-04 hepatocytes facilitate CRISPR-based analysis of <i>Plasmodium falciparum</i> sporozoite-host interactionsSemantic proximity Read ↗

Parasite and host kinases as targets for antimalarialsSemantic proximity Read ↗

Polo-like kinase 1 regulates growth in juvenile <i>Fasciola hepatica</i>Semantic proximity Read ↗

A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and InvasionSemantic proximity Read ↗

Plasmodial Kinase Inhibitors: License to Cure?Semantic proximity Read ↗

The Selection of a Hepatocyte Cell Line Susceptible to Plasmodium falciparum Sporozoite Invasion That Is Associated With Expression of Glypican-3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.