Article

A High-Throughput Screen Reveals the Structure-Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin

2022-12-13

Abstract excerpt

The Burkholderia cepacia complex (Bcc) is a group of bacteria including several opportunistic human pathogens. Immunocompromised individuals and cystic fibrosis patients are especially vulnerable to serious infections by these bacteria, motivating the search for compounds with antimicrobial activity against the Bcc. The natural product ubonodin is a lasso peptide with promising activity against several Bcc specie...

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Literature Corpus work: 2479bd96-a714-5b0a-a056-7b2e23647974
DOI: 10.1101/2022.12.13.520261

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