Article

Genome-wide pQTL mapping in human skin identifies specific genetic regulators and mechanistic links to skin disorders

2026-08-15

Abstract excerpt

Understanding how genetic variation shapes tissue-specific protein expression is fundamental for uncovering disease mechanisms and therapeutic targets. However, the proteomic landscape and its underlying genetic regulation in skin, the largest human organ, remain largely uncharted. Here, we present a population-level skin proteomic dataset, quantifying 5,774 proteins across 248 individuals and revealing substantia...

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Literature Corpus work: 2920542f-f8d0-5f7b-86fb-1de8e691cf6b
DOI: 10.1038/s41467-026-76575-4

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