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Article

<i>De novo</i> synthesis of a conjugative system from human gut metagenomic data for targeted delivery of Cas9 antimicrobials

2023-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Metagenomic sequence represents an untapped source of genetic novelty, particularly for conjugative systems that could be used for plasmid-based delivery of Cas9-derived antimicrobial agents. However, unlocking the functional potential of conjugative systems purely from metagenomic sequence requires the identification of suitable candidate systems as starting scaffolds for de novo DNA synthesis...

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Literature Corpus work
290db793-00a2-5cbf-aa29-ee56bcc9cbb3
DOI
10.1101/2023.05.10.540216
Open publication

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<i>De novo</i> synthesis of a conjugative system from human gut metagenomic data for targeted delivery of Cas9 antimicrobialsDOI 10.1101/2023.05.10.540216
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