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Immune Response to Group A Streptococcal C5a Peptidase in Children: Implications for Vaccine Development

9 Sept 2003

Abstract excerpt

The group A streptococcal C5a peptidase (SCPA) is a major surface virulence protein that facilitates the establishment of local infection by group A streptococci (GAS). We measured the human immune response to SCPA, using a standardized indirect enzyme-linked immunosorbent assay. Paired acute and convalescent serum samples from children with GAS-associated pharyngitis were assayed, and a strong immune response to...

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PMID: 12964111
DOI: 10.1086/377700

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